Adapting Biophysics for the RNA–Protein Interface to Tackle Large, Dynamic RNP Assemblies in Drug Discovery
- Interrogate the unique structural and dynamic challenges of RNA–protein complexes, from disorder and charge density to multi-component assemblies with shifting stoichiometry
- Explore biophysical and biostructural methods adapted for RNP systems including strategies to minimize artefacts, probe conformational heterogeneity, and capture transient or cooperative interactions
- Discuss how hybrid approaches strengthen characterization of RNP behavior, revealing functional mechanisms and improving targetability for emerging therapeutic modalities