Adapting Biophysics for the RNA–Protein Interface to Tackle Large, Dynamic RNP Assemblies in Drug Discovery

• Interrogate the unique structural and dynamic challenges of RNA–protein complexes, from disorder and charge density to multi-component assemblies with shifting stoichiometry
• Explore biophysical and biostructural methods adapted for RNP systems including strategies to minimize artefacts, probe conformational heterogeneity, and capture transient or cooperative interactions
• Discuss how hybrid approaches strengthen characterization of RNP behavior, revealing functional mechanisms and improving targetability for emerging therapeutic modalities

Speakers:

Bryan Dunyak

Director, Biomolecular Sciences & Lead Discovery

Remix Therapeutics