Fragment-Based Discovery of Reveals Unprecedented Ligandability and Enables Direct Targeting of a Cancer-Relevant Transcription Factor
Time: 12:45 pm
day: Day 2
Details:
- Transcription factors remain of high interest in oncology and other disease areas
- Direct targeting of certain classes or domains of transcription factors is unexplored, and they are considered undruggable
- Fragment screening and optimization, driven by multiple orthogonal biophysical techniques coupled with structure-based design, enabled the discovery of ligands targeting such a transcription factor
