Quantifying Reversible & Irreversible Interactions of Covalent Small Molecule Binders to Non-Enzyme Targets Using Biophysical Methods
- Explore the considerations for use of different techniques (MS, FRET, SPR, spectral shift) to measure compound potency through kinetic measurements
- Discuss how to implement experimental setups and kinetic modeling for characterization of covalent kinetics by SPR
- Present how information from orthogonal techniques can be combined for greater understanding of covalent compound interactions