Integrating Orthogonal Biophysical Techniques to Build a Confident Binding Narrative for Challenging Targets
- Explore how combining complementary assays (SPR, ITC, NMR, crystallography, DSF, native MS, and DEL screening) enables robust validation of binding events
- Learn how multi-technique strategies can identify novel binding sites, confirm fragment hits, and map allosteric mechanisms, even for RNA-binding or otherwise difficult proteins
- Gain insight into how solution-based, structural, and label-free techniques can converge to tell a consistent story that strengthens confidence in hit identification, characterization, and progression