SPR Methodologies to Advance Early Small-Molecule Programs for Challenging Membrane Protein Targets
- Address key obstacles in SPR analysis of membrane proteins, including protein instability on the sensing surface and interference from detergent micelles
- Showcase strategies for optimal detergent selection and membrane-protein stabilization to preserve activity during SPR experiments
- Demonstrate how these optimized conditions enable reliable interaction profiling between small molecules and diverse membrane-protein classes