Discovery of Reversible Inhibitors of RNA-Modifying Enzymes

Time: 9:30 am
day: Conference Day Two


  • Explore the identification and characterization of modulators of exonuclease XRN1, where surface plasmon resonance (SPR) played a critical role in validating and progressing an initial small molecule hit into optimization
  • Learn about the Hit ID and optimization of small molecule inhibitors of DExH-Box
  • Helicase DHX9, where a toolbox of biochemical and biophysical assays progressed an initial hit with partial ATPase inhibition to a Development Candidate