Modi Sathappa
Principal Scientist Kymera Therapeutics
Seminars
Thursday 30th April 2026
Utilizing Biophysics for Targeted Protein Degradation to Deconvolute Ternary Complex Formation, Cooperativity, & Kinetics
11:00 am
- Exploring the additional complexities involved in studying dynamic protein degraders
- Understand how biophysics can guide degrader design by revealing ternary complex stability and lifetime
- Discuss design of in vitro systems that better predict cellular degradation outcomes to enhance predictive ability of assays
- Specific methods employed to tease apart affinities and cooperativity in protein complexes and how these insights contribute to the selection and optimization of degrader molecules
