Pooja Sharma

Pooja Sharma, Principal Scientist at Amgen, is an accomplished discovery scientist with extensive expertise in biophysical, biochemical, and structural techniques spanning small molecules, peptides, membrane proteins, and RNA targets. She brings deep experience in SPR, NMR, X-ray crystallography, DSF/TSA, ITC, MST, and AI-enabled analyses, alongside broad proficiency in soluble and membrane protein expression systems, including SMALPs and nanodiscs. Pooja has contributed to fragment-based lead discovery at Harvard Medical School and the Walter and Eliza Hall Institute and has enabled multiple early discovery programs by overcoming complex mechanistic and assay challenges. Her current work focuses on advancing alternative biophysical approaches for challenging membrane targets.