Rob Van Montfort

Company: Institute of Cancer Research

Job title: Group Leader Hit Discovery & Structural Design

Seminars:

Deconstruction of HTS Hits Into Fragments As A Route To Discover Potent BCL6 Inhibitors & Degraders 2:30 pm

A comprehensive hit id campaign including VS, HTS and FBS combined with integrated orthogonal biophysical approaches (TSA, SPR, LO-NMR) was crucial in the validation of initial BCL6 screening hits Deconstruction of the initial HTS hits into smaller fragments improved solubility and facilitated the structure-based drug design to increase potency Biophysical validation using orthogonal techniques enabled…Read more

day: Day 1