Roman Agafonov

Roman Agafonov is Associate Director of Biochemistry, Biophysics & Structural Biology at C4 Therapeutics, where he leads biochemistry and biophysics strategy for targeted protein degradation programs. With more than 15 years of experience in mechanistic characterisation of protein–protein and protein–small molecule interactions, Roman oversees hit identification, new target evaluation, and the integration of advanced screening and structural methods to understand degrader behaviour. He has extensive expertise in dissecting ternary complex formation, cooperativity, and kinetics to guide degrader design. At the Summit, Roman will discuss how biophysics can enhance prediction of cellular degradation outcomes and support degrader optimisation.